The possibility of allergic sensitivity, including an anaphylactoid reaction, should be kept in mind.Ĭertain allergic manifestations, although rare, may occur following Intramuscular or Subcutaneous administration. Pain, swelling, and tenderness at the injection site may occur. (See Box Warning at Beginning of Circular). Temporary resistance to prothrombin-depressing anticoagulants may result, especially when larger doses of phytonadione are used.ĪDVERSE REACTION: Deaths have occurred following intravenous injection. Failure to respond to vitamin K may indicate that the condition being treated is inherently unresponsive to vitamin K. Repeated large doses of vitamin K are not warranted in hepatic disease if the response to the initial therapy is unsatisfactory. Phytonadione will not counteract the anticoagulant action of heparin.

Whole blood or component therapy may be necessary if the bleeding is severe. A minimum of 1 to 2 hours is required for measurable improvement in the prothrombin time. WarningsĪn immediate coagulant effect should not be expected after administration of phytonadione. Hypersensitivity to any component of this medication. The dosage should be adjusted accordingly.

NOTE: Regular determinations of prothrombin time response should be performed to guide in the initial and subsequent administration of Vitamin K 1 Injection. Vitamin K 1 Injection is also indicated to counter hypoprothrombinemia caused by consumption of Bishydroxycoumarin found in spoiled and moldy sweet clover.

Vitamin K 1 Injection is indicated in cattle, calves, horses, swine, sheep, goats, dogs and cats to counter Hypoprothrombinemia induced by ingestion of coumarin-based compounds, common ingredients in commercial rodenticides. A normal prothrombin level may often be obtained in 12 to 14 hours. The action of the aqueous colloidal solution, when administered intravenously, is generally detectable within an hour or two and hemorrhage is usually controlled within 3 to 6 hours. The mechanism by which vitamin K promotes formation of prothrombin at the molecular level has not been established. The primary function of vitamin K is to stimulate the production via the liver of active prothrombin from a precursor protein. ACTIONS: Vitamin K 1 Injection, an aqueous colloidal solution of Vitamin K 1 for parenteral injection, possesses the same type and degree of activity as does naturally occurring Vitamin K.

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